A pharmaceutical composition which has a plurality of lipid nanoparticles that has a mean particle size of between 80 nm and 160 nm and contains a modified mRNA encoding a polypeptide. The lipid nanoparticles include a ionic lipid, a neutral lipid, a cholesterol, and a PEG lipid. The mRNA contains a 5′cap, 5′UTR, N1methylpseudouridine, a 3′UTR, and a polyA region with at least ...
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